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Glucose consumption, lactate production, total ATP content and insulin secretion were determined after 24 hours of incubation in the absence of Exendin-4 (Fig

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In particular, increased plasma insulin concentrations stimulate the gonadotropin releasing hormone (GnRH) pulsatility and potentiate the LH-dependent effect on the ovarian theca cells, leading to the enhanced synthesis of androgens and to the arrest of pre-antral follicle development [13]

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