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Updated: 4 hours ago | FOX Carolina's Ashley Listrom has the details.

The insight behind retatrutides design is that when glucagon receptor activation is combined with GLP-1 and GIP agonism which themselves stimulate insulin release and improve insulin sensitivity the blood sugar-raising effect of glucagon is counterbalanced, leaving only the beneficial energy-expenditure and fat-burning effects

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If this pattern holds for retatrutide, nasal delivery could offer a GI-tolerability advantage for individuals who respond well to the central appetite effects but struggle with peripheral GI symptoms