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The mechanism is well-characterized in rodent models but not confirmed at the tissue level in human injectable studies for musculoskeletal indications

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Following a months-long safety review, the EMAs Pharmacovigilance Risk Assessment Committee concluded that semaglutide, the active ingredient in Ozempic, Wegovy, and Rybelsus, is associated with rare occurrences of non-arteritic anterior ischemic optic neuropathy (NAION), a condition caused by reduced blood flow to the optic nerve