Oral forms may work well for gut-related issues since the peptide contacts digestive tissues directly
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doi: 10.1086/342600
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On the other hand, the vicious course induced by high intra-abdominal pressure can be simultaneously initiated and perpetuated from different sites (it should be noted that intracranial hypertension may essentially cause pulmonary edema and impair pulmonary circulation (Chen, 2009))