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However, it is important to note that type 2 diabetes, obesity, and metabolic dysfunction may specifically increase the likelihood of developing HFpEF more than HF with reduced ejection fraction (HFrEF) (Samson et al., 2016)

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5 GI events like nausea, diarrhea, constipation, vomiting, and dyspepsia were the most frequently reported adverse effects

This, in turn, mediates their retention in the spleen and finally leads to hemolysis and removal of the cellular ghosts by macrophages [213, 221]

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