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This mirrored pattern between glycolysis and OXPHOS can be explained by the observation that columnar chondrocytes in the central region of the growth plate are the most distant from blood vessels and thus reside in a more hypoxic region, whereas resting and hypertrophic chondrocytes localize closer to the vasculature, allowing for oxygen-consuming glucose catabolism, as evidenced by transgenic mouse models 4,6,21