Apart from delivering the Se from the liver to other parts of the body, it also exerts enzymatic antioxidant (peroxidase) activity in plasma, notably against peroxynitrite-mediated oxidation, nitration, and nitrosation (7779), and against lipid hydroperoxides formed by lipoxygenases and cyclooxygenases, thus protecting circulating lipoproteins (phospholipids) and cholesterol from oxidation (57, 8082)
Exposure to TMAO decreases pyruvate metabolism ( via impaired substrate flux through pyruvate dehydrogenase), impairs -oxidation, and affects energy metabolism in cardiac muscle fibers, leading to the development of HF (Makrecka-Kuka et al., 2017)
To overcome this limitation, the pharmaceutical industry developed GLP-1 analogs, compounds designed to mimic the hormones action while extending its duration
[1] [2] They work by mimicking the action of glucagon-like peptide-1, a naturally occurring hormone produced in the intestine
The lack of data regarding exposure specifically during the first trimester is unfortunate
doi: 10.1371/journal.pone.0152925
