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Furthermore, using contrast variation, it was shown that the nucleosome unfolding induced by a decrease in ionic strength represents a complex process, where DNA became partially unfolded below the transition point, whereas only small conformational changes occur in the protein core (Uberbacher et al., 1983)

The use of nucleic acids or nucleic acid analogues that may alter genome sequences and/ or alter gene expression by any mechanism

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doi: 10.1016/0006-291x(80)91433-3