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Discomfort is minimal

Yes, certain medications promote weight gain and can counteract GLP-1 effects, including antipsychotics (olanzapine, clozapine), mood stabilizers (valproate, lithium), some antidepressants (mirtazapine, paroxetine), corticosteroids, and diabetes medications like insulin or sulfonylureas

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Unfortunately, current AOM options are limited and only a small fraction of eligible patients are actually offered pharmacologic treatment

Subcutaneous semaglutide 1.0 mg dose and oral semaglutide 14 mg dose monotherapy resulted in HbA1c reductions of 1.6% (at 30 weeks) and 1.4% (at 26 weeks), respectively, compared to the placebo group

Lifestyle modifications remain the cornerstone of safe weight management: Dietary interventions : A modest calorie deficit (typically 500600 kcal/day) achieved through balanced nutrition rather than restrictive dieting