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For example, From a drug-development perspective, METRNL illustrates the limitations of receptor-centric paradigms

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Dose increase protocol (every 4 weeks) One week before your planned dose increase, ensure you have adequate medication for the new dose level

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It affects several liver enzymes (including CYP3A4, CYP2D6 and CYP2C9) that process common drugs, and it may interact with medications such as metformin