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Currently, treatment of insomnia in T2DM primarily involves symptomatic therapies, including relief of pain, adherence to good sleep hygiene, and use of hypnotics such as benzodiazepine receptor agonists and zolpidem

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Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects

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