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When cultured human L-cells were deprived overnight of glucose and serum and then exposed to high glucose, 10% FBS, and -carrageenan (1 g/ml) for 10 minutes, 1 h, and 24 h, mRNA expression of proglucagon and secretion of GLP-1 were significantly reduced, compared to control cells not exposed to carrageenan

Adverse events with tirzepatide were mainly gastrointestinal-related and mostly mild to moderate in severity

Evoke+ also includes a proposed subset of participants with vascular co-pathology, which will enhance the representativeness of the study population

The medications are generally well-tolerated, though gastrointestinal side effects such as nausea, vomiting, and diarrhoea are common, particularly during dose titration

Quick Answer: GLP-1 medications do not directly cause increased thirst, but some patients experience it as an indirect consequence of gastrointestinal side effects like vomiting or diarrhea that lead to dehydration

18 Collart J, Vandeponseele M, Bosschaert P