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doi: 10.3389/fnins.2021.662242 Summary Keywords Alzheimer's disease, brain energy metabolism, emerging interventions, insulin resistance, metabolic dysfunction, mitochondrial failure, neurodegeneration, oxidative stress Citation Xiao X, Yan X, Liang C and Yang Y (2026) Metabolic dysfunction and mitochondrial failure in Alzheimer's disease: integrating pathophysiology, clinical evidence and emerging interventions