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With the advance of combination therapy, the combination of targeted IGFs and other technologies for the treatment of tumors has shown advantages, which not only increase the efficacy but also effectively prevent the occurrence of drug resistance

Among these, artesunate, sevoflurane, dihydroartemisinin, brusatol, nisin, hederagenin, glaucocalyxin A, nootkatone, cannabinoids and ophiopogonin B successfully promote ferroptosis in diverse cancer cell types mediated by the ER stress branch ATF4-CHOP-CHAC1 (Lu et al., 2024

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