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Conclusion Across topical and tissue models, GHK-Cu is studied for potential roles in matrix support, wound-area remodeling signals, oxidative balance, and inflammation moderation

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Several studies have adopted composite indices such as the Systemic Immune-Inflammation Index (SII = platelet neutrophil/lymphocyte), which integrates PLR and NLR components and outperforms either marker alone in predicting postoperative outcomes and survival in ESCC cohorts (98, 99)

Approval was granted by the Ethics Committee of King Abdullah University Hospital University (Date 09/14/2021/No 2021/143/2)