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The future of medical weight loss is becoming increasingly personalised

10.1038/s41392-022-00904-4 Summary Keywords peptide drug, immunogenicity, immunoinformatic analysis, T cell epitope, HLA binding, D-amino acid, unnatural amino acid (UAA), impurity Citation Mattei AE, Gutierrez AH, Martin WD, Terry FE, Roberts BJ, Rosenberg AS and De Groot AS (2022) In silico immunogenicity assessment for sequences containing unnatural amino acids: A method using existing in silico algorithm infrastructure and a vision for future enhancements

It was developed by Eli Lilly and gained FDA approval in May 2022 for type 2 diabetes (Mounjaro), followed by FDA approval for chronic weight management in November 2023 (Zepbound)

Moreover, researchers are developing various combined carrier-use modes to facilitate effective drug loading, precise targeting, and release

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Nucleic Acids Res Spec Publ