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People who are pregnant or breastfeeding (many medications lack sufficient safety data)

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These stiff gels activate the mechanosensitive ion channel (MIC) TRPV4, which upregulates the activity of the phatidylinositol 3-kinase(PI3k)/Akt pathway, triggering the expression of heat shock protein-(HSP-) 70, which protects against stress-induced cell death [119]

These changes in mental health can have a strong impact on sex drive

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