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Metabolic summation refers to the point where energy is depleted, no more ATP is produced, and your body starts depending on anaerobic respiration

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DOI: 10.1155/2016/3164734 21

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Such depletion can be due to reduction of GSH due to excessive NAPQI exposure and/or to GSH depletion associated with elevated dopamine secondary to dopamine -hydroxylase inhibition by phenolic Clostridia metabolites