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Croatia: InTech

DOI 10.1056/NEJMoa2413258 Tirzepatide Jastreboff AM et al

GLP-1-driven weight loss works more slowly and less dramatically, but it treats the cause rather than overriding it, and it tends to improve testosterone and semen quality instead of suppressing them

Total loss by week 24 averages 15 to 18% of starting weight

The cumulative mortality rates per 1000 person-years for all-cause was 37.60, 61.46 and 102.62 for patients with MMA levels in T1, T2 and T3, respectively (Fig