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Also, the significant upregulation of plasma proteins (IGFBP4, fetuin-B, tetranectin, and vitamin K-dependent protein S) was tentatively proposed to be associated with osteoclast activity

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These were secondary, explorative outcome variables, and the number of patients to evaluate by the iohexol plasma clearance technique and hyperinsulinemiceuglycemic clamp was not calculated a priori on the basis of an expected treatment effect, but was dictated by feasibility, considering that both procedures are time- and cost-consuming and demanding for both patients and investigators

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