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The infection experiments were performed with SARS-CoV-2 Munich isolate (CSpecVir985) under biosafety level 3 conditions with appropriate respiratory personal protection equipment

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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation