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By acting as a co-agonist for both the GLP-1 receptor agonist and amylin pathways, amycretin aims to provide even greater weight reduction than medications that only target GLP-1

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Mazdutide is a dual GLP-1/glucagon receptor agonist, offering: - Once-weekly dosing - Strong metabolic impact - Favorable safety profile (mostly GI-related) Why It Matters

The article says weight loss can temporarily shift thyroid hormone metabolism, and that TSH and free T4 levels may fluctuate modestly as body composition changes on GLP-1 therapy