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Male C57BL/6 mice (78 weeks old, 2528 g) were purchased from the Institute of Laboratory Animal Science at the Chinese Academy of Medical Sciences (Beijing, China) and housed in a specific pathogen-free facility maintained at 2022 C, with cycles of 12 h light-dark and food and water ad libitum

It belongs to a class of medications called glucagon-like peptide-1 receptor agonists (GLP-1 RAs) (3)

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Injectable: Subtle improvements may appear at weeks 2-3

Accumulating evidence supports the role of ER in regulation of necroptosis