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and the content of GPX4, -glutamylcysteine synthetase modifying subunit (GCLM), FTH, nuclear factor E2-associated factor (Nrf2), and Kelch-like epoxide-associated protein 1 (Keap1), P62 (Sequestosome1), and heme oxygenase 1 (HO-1) was detected by Western blot and RT-qPCR in the colon tissue

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doi: 10.1160/TH14-07-0637

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When glutathione neutralizes these triggers, the melanocytes are not as "alarmed" and do not feel the need to overproduce pigment as a protective response

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