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Concurrently, GLP-1 also reduces fat build-up in the liver by activating AMPK, which then inhibits fatty acid synthesis while promoting the breakdown of fatty acids (beta-oxidation), leading to less lipid droplet accumulation in hepatocytes
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This is what phase 2 clinical trial data published in the New England Journal of Medicine actually demonstrated for retatrutide , the triple-receptor agonist that produced weight reduction numbers researchers had never seen before in obesity pharmacotherapy
Except we kind of already do
The solution: Consider breaks after 12 to 16 weeks of use, or experiment with dosage cycles