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LOW DOSES (1-2 ug/kg/min) it selectively activates D1 receptors The D1 mediated effect to increase renal blood flow may be of clinical significance (e.g
Some researchers have speculated that patients in certain clinical trials, particularly the CASTA stroke trial, may have received inadequate doses, potentially explaining the mixed results in the overall population analysis
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Available from: Fletcher AL, Lowen TE, Sakkal S, Reiseger JJ, Hammett MV, Seach N, et al
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The finding of distinct central populations of Gipr -expressing neurones in the AP and hypothalamus underlying responses to agonism and antagonism, respectively, goes some way towards resolving the dilemma of agonism and antagonism having similar outcomes
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