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1 Introduction All tissues and organs in our bodies contain fibroblasts, a type of spindle-shaped cells which produce the connective tissue that provides structural support to the parenchymal cells ( th century when Virchow, Ziegler and Ramon y Cajal identified and provided the first clues about the existence and the functions of these cells ( Although a single name is used to refer to fibroblasts, they represent a highly heterogeneous population, with different subtypes identified depending on the specific tissue, their location within each tissue, pathophysiological status and cellular origin