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The Wegovy FDA label carries a clear precaution against use in pregnancy, and animal studies at exposures below the human clinical dose showed embryofetal toxicity including reduced fetal growth and skeletal malformations
6,8 Studies looking at higher doses, such as one comparing 12.5mg, 25mg, and 50mg, found a non-dose-dependent steady-state level maximum at the 25mg dose
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The drug was approved only for maintenance therapy in acromegaly patients already stabilized on injectable octreotidenot for treatment-nave patients