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In the case of 2-hydroxyglutarate instead, it seems to induce an abnormal activity of telomerase reverse transcriptase (TERT), which in turn upregulates the transcription of important genes involved in stemness and tumorigenicity, including CD117, Oct4, and Sox2 [84, 85]
Safety screening should consider thyroid cancer history, multiple endocrine neoplasia type 2, pancreatitis, gallbladder disease, kidney disease, severe stomach-emptying problems, diabetic eye disease, eating disorders, pregnancy plans, and breastfeeding
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The role of the IGF-1 signaling Cascade in muscle protein synthesis and anabolic resistance in aging skeletal muscle
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