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In the United States, a combination product containing topiramate and phentermine (Qsymia) is approved for obesity management, but this combination is not licensed by the MHRA for use in the UK

Lancet Gastroenterol Hepatol Mantelmacher FD, Fishman S, Cohen K et al (2017) Glucose-dependent insulinotropic polypeptide receptor deficiency leads to impaired bone marrow hematopoiesis

Diabetes Care , 44 (1), 290-296

Discontinue JANUMET XR if the patient's eGFR later falls below 30 mL/min/1.73 m2 [see Contraindications (4)]

For many people, the weight-loss journey with semaglutide extends beyond the initial 5 to 6 months

It affects a significant number of users, and for some, it can be disruptive