glp-1 overview Frontiers Mechanisms of action of GLP-1RA.

They use prebiotic fiber, probiotics (like Akkermansia muciniphila ), and metabolic compounds (berberine, chromium, 5-HTP) to nudge the body's own GLP-1 production

European Journal of Preventive Cardiology

A 48-week phase 2 obesity study demonstrated weight reductions of 22.8% and 24.2% with retatrutide 8 and 12 mg, respectively

6,8 To date, tirzepatide has achieved an unprecedented effect on improving Hemoglobin A1c (HbA1c) and body weight in T2DM patients

Storoni M, Chan CK, Cheng AC, Chan NC, Leung CK

Some patients may require more aggressive dosing while others may be quite sensitive and opt to remain at lower doses