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Some individuals continue to experience mild constipation or occasional nausea beyond week three, especially if they jump to higher doses too quickly

Krieger JP (2020) Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms

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Zhang L, Li L, Hlscher C

The search included combinations of the following terms: tirzepatide, GIP receptor agonist, GLP-1 receptor agonist, gut microbiota, obesity, metabolites, inflammation, and host metabolism. Additional relevant articles were identified through manual screening of reference lists from selected publications