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Under oxidative stress, accumulation of ROS can activate pathways such as the JNK and the p53, further inducing autophagy, which helps clear damaged organelles, reduces oxidative damage, and protects cell survival [256]

Using integrated genomic analyses, we characterized extensive NRF2-dependent enhancer RNA (eRNA) synthesis and NRF2-mediated H3K27ac deposition at proximal and distal enhancer regions regulating these genes

Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-kappaB signaling pathways

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Dragan, S., Serban, M