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M2 macrophages mainly rely on oxidative phosphorylation to perform their immune function, whereas M1 macrophages rely on glycolysis (14)

The dose-response curve has flattened substantially by 4 to 6 mg, while heart-rate and gastrointestinal costs continue to rise above it

Drugs Today 43 , 1325 (2007)

Vitamin B12 (Methylcobalamin, 1 mg) a cofactor in methylation and cellular energy production pathways

While these medications were originally developed for type 2 diabetes and later gained widespread use for obesity management, researchers are now examining whether they may also improve pain, stiffness, and mobility

Most common side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation