ros glutathione On the Role of and in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin Team:UNSW Australia/Model/Glutathione System

Ethics declarations Ethics approval Animal care and procedures were conducted according to the guidelines approved by the French Ethical Committee (decree 87 to 848) and by the European Community directive 86 to 609-EEC

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In addition, the inner-mitochondrial-membrane enzyme dihydroorotate dehydrogenase (DHODH) transfers electrons derived from pyrimidine synthesis to ubiquinone, reducing it to ubiquinol and thereby suppressing ferroptosis in parallel with mitochondrial GPX4 (Mao et al., 2021)

Homocysteine can also be produced by the metabolism of excess methionine

PMID: 32816946