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NGF and its receptors in the regulation of inflammatory response

Surprisingly, the SURMOUNT-5 trial found that fewer people discontinued tirzepatide due to side effects (2.7%) compared to semaglutide (5.6%)

Clinical trials showed joint pain rates similar to placebo, indicating no established direct causal relationship

That can lead to immediate side-effects including: Nausea and vomiting Diarrhea Constipation and abdominal pain Bloating Dizziness Fatigue This is a fairly common laundry list of the sort of side effects you get when you are messing around with the human digestive system

10.1523/JNEUROSCI.0426-16.2016 10 AlamZ

This is exciting research, but GLP-1 drugs are not a cure for OA