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Metformin is known to be associated with gastrointestinal side effects, including diarrhea, in some individuals
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The researchers identified the bacterial caseinolytic protease (ClpP) as the ADEP target, demonstrating that ADEPs bind to ClpP, activate the otherwise inactive Clp-protease complex, and disrupt essential bacterial protein regulation, potentially accounting for their potent antibacterial effects
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Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
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