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However, the ceramide analog, C2-ceramide, activated PP2A but not PKC and inactivated Akt activity in brown adipocytes [134], which suggested PP2A might mediate the role of ceramide in insulin resistance

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A median of 5 BMI measurements were contributed per person (interquartile range: 3-7)

Besouw MT, Holewijn S, Levtchenko EN, Janssen MC (2011) Non-invasive measurements of atherosclerosis in adult cystinosis patients

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Insulin resistance can enhance biliary cholesterol secretion via dysregulation of the hepatic transcription factor forkhead box protein O1 (FOXO1) and has effect on the cholesterol transporters ABCG5 and ABCG8