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In one study, more than half the participants (54%) had no previous use of oral glucose-lowering medication [22], while in another study, all participants were on a stable dose of insulin glargine with (83%) or without (17%) metformin [19]

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In other rodent work, subcutaneous administration has been used, particularly for systemic-effect studies

The depot effect in subcutaneous adipose tissue isn't a limitation

Temperature: Occasionally, if IV fluids are colder than your body temperature, you may feel chills or discomfort