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Overactivation, especially via the GluN2B subunit with its slow channel kinetics, increases susceptibility to excitotoxic damage and psychiatric disorders [79]

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Valdivielso et al., 2017)

Typical concentrations range from ~0.1 mM to 10 mM , depending on: Cell type (e.g., hepatocytes, neuronal cells, fibroblasts) Oxidative stress conditions (e.g., HO exposure models) Duration of exposure (acute vs