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Age-related considerations include: Younger adults (18-30) May tolerate dose escalation well but should still follow standard protocols

Wang YA, Sun Y, Palmer J, Solomides C, Huang L-C, Shyr Y, et al

These approaches, which focus on mitochondrial function, aim to restore organelle homeostasis and delay ovarian functional decline (Table 1)

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The exclusion criterion was that subjects were excluded if pregnant or suspected to be pregnant, applied only to female subjects