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Patients were grouped into nondiabetic or type 2 diabetic cohorts, then each patient on a GLP-1 was matched to four patients who were not prescribed a GLP-1 based on age at bone density disorder diagnosis, total observed time with the condition, and number of prior fractures

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doi: 10.1056/NEJMoa2206038 83 US National Institutes of Health

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Papers were excluded if they were review papers, if the study was conducted only on animals, if there was no measurement of ghrelin or GLP-1, or administration of an agonist or antagonist for the respective receptors, or when the hormonal measure or manipulation was not related to the reward response

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