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To overcome these limitations, future studies should focus on refining organoid coculture systems, integrating tumor-immune components, and developing short-term dynamic models that preserve cellular heterogeneity and better simulate in vivo conditions

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484 This necessitates the development of innovative therapeutic strategies that specifically target CSCs while minimizing off-target effects on NSCs

Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation

PMID: 29565716