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By targeting both receptors, Tirzepatide enhances insulin secretion and reduces glucagon secretion in a glucose-dependent manner, contributing to improved glycemic control

This is where some patients choose to stay rather than continuing to escalate

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Some patients report initial insomnia or vivid dreams during the first 24 weeks of semaglutide treatment, while others experience improved sleep as weight loss progresses and sleep apnea improves

Adverse Reactions with Concomitant Use with Insulin In the add-on to insulin trial [see Clinical Studies (14.1)], the incidence of adverse events, including serious adverse events and discontinuations due to adverse events, was similar between saxagliptin and placebo, except for confirmed hypoglycemia [see Adverse Reactions (6.1)]