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, it was found that when LD is used on UF-induced rats, the expression of IGF-I and PCNA mRNA were significantly reduced as compared to the model group, suggesting its ability to reduce leiomyoma cell proliferation via this mechanism

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289 At the same time, the promotion of CD8 + T cell activation and recruitment and significant inhibition of MDSCs generation and recruitment were observed in models treated with L-DON and JHU-083

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In anterior compartment, Hh binds to receptor Patched (Ptc) to derepress the activity of a transmembrane protein Smoothened (Smo) 44, 46, 47