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Clinical trials show significant HbA1c improvements by month 3, with continued improvement through month 6 when combined with lifestyle changes

303 Moreover, hepatic iron accumulation can induce the transcription expression of ACSL4 by activating the transcription factor c-Myc, and further aggravate the development of MASH through ferroptosis

It is also important to note that Mounjaro may reduce the effectiveness of oral contraceptives , particularly during the initial weeks of treatment or after dose increases, due to delayed gastric emptying

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