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JAMA Health Forum

Following dissociation, islets cells were washed 3 times with PBS containing 0.01% BSA, followed by centrifugation at 352 g for 5 minutes, and then resuspended in PBS containing 0.01% BSA at a concentration of approximately 250,000 cells/mL, which was used for downstream DROP-Seq and DART-Seq experiments

Once someone has done all the right things for nutrition, fitness, sleep, stress management, and frailty prevention, then having a conversation about adding a pharmacologic option for longevity or optimization becomes appropriate. The Takeaway GLP-1 medications, like semaglutide and tirzepatide, were originally developed for diabetes, but researchers are now exploring if they may extend lifespan and help people maintain good health for a longer period of time

Activity assays

Phase 3 results are expected throughout the remainder of the TRIUMPH program, with potential FDA approval estimated for 2027 at the earliest

However, due to cost concerns, some healthcare providers are prescribing GLP-1 alternatives, such as SGLT2s (sodium-glucose cotransporter 2 inhibitors), for addressing cardiovascular risk