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Recent experimental and clinical observations [15, 19, 23] hint at GLP-1RAs acting as modulators of neuroinflammation, oxidative stress, and neurogenesis, providing a broader framework for their potential impact on psychiatric conditions

Methods Protocol and registration The present systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure methodological rigor and transparency

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tirzepatide is contraindicated in individuals with personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia type 2 syndromes (54, 61)