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The natural production of SAL is limited by plant growth conditions, low content, and difficult extraction, while chemical synthesis is hindered by its complex structure, lengthy procedures, and high cost, leading to supplydemand imbalance (Sun et al., 2025)

PPAR, peroxisome proliferatoractivated receptor

This is why many people choose a bioavailable supplement to ensure their levels remain optimal

If cognitive symptoms persist, consider magnesium threonate specifically, as it is the only form shown to effectively cross the blood-brain barrier and increase brain magnesium levels

[DOI] [Google Scholar] Weir NA

doi: 10.1016/0896-6273(89)90043-3