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For xenobiotic-induced cell death and inflammation, the severity of the lesions is often a function of the dose of the hepatotoxicant

L-Glutathione is an antioxidant that helps to protect cells from damage caused by free radicals and toxins

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The IV protocol can change based on the situation

Additionally, ethics related to animal welfare, and changes in the legislation in several geographies have motivated the development of more human-relevant tools and approaches that do not rely on the generation of new animal data to test chemicals (Brescia et al., 2023